Adipocytes Promote Breast Cancer Cell Survival and Migration through Autophagy Activation

White adipose tissue interacts closely with breast cancers through the secretion of soluble factors such as cytokines, growth or fatty acids. However, molecular mechanisms these interactions and their roles in cancer progression remain poorly understood. In this study, we investigated role acids cooperation between adipocytes cells using a co-culture model. We report that increase autophagy acidification lysosomes, leading to cell survival nutrient-deprived conditions migration. Mechanistically, disturbance membrane phospholipid composition decrease arachidonic acid content is responsible for activation induced by adipocytes. Therefore, might be central cellular mechanism white thus participate progression.